Research@IITD :: Decoding Protein Dendrimers

A new scientific paper published by Prof. V. Haridas research group from the Chemistry Department of IIT Delhi has summarized the stepwise evolution of peptidic dendrimers along with their multifaceted applications in various fields besides articulating an overview of state-of-the-art in this field.

The 51-paged paper appeared recently in the Chemical Reviews of the American Chemical Society Journal that has an impact factor of 54.3.

“Dendrimers have attracted immense interest in science and technology due to their unique chemical structure that offers myriad of opportunities for researchers. Dendritic design allows us to present peptides in a branched three-dimensional fashion that eventually leads to a globular shape, thus mimicking globular proteins. Peptide dendrimers, unlike other classes of dendrimers, have immense applications in biomedical research due to their biological origin. The diversity of potential building blocks and innumerable possibilities for design, along with the fact that the area is relatively underexplored, make peptide dendrimers sought-after candidates for various applications,” says the paper titled-- Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis

“The introduction of biomacromolecules such as proteins to a dendritic scaffold, resulting in complex macromolecules with discrete molecular weights, is an altogether new addition to the area of organic chemistry. The synthesis of highly complex and fully folded biomacromolecules on a dendritic scaffold requires expertise in synthetic organic chemistry and biology. Presently, there are only a handful of examples of protein dendrimers; and this will fuel further research in this area,” the research paper adds.

“Peptide dendrimers are special molecules with radiating branches and numerous groups on the surface. Peptide dendrimers are compared to trees because of its branched architecture.These molecules are the most sought after candidates for a variety of applications in the area of science and technology because of its unique anatomy with a large number of surface groups. The translating research from bench to bedside requires joint efforts by scientists working across various disciplines, “ Prof V Haridas, the lead author of the study maintains.

The link to the paper is (Sapra, R.; Verma, R. P.; Maurya, G. P.; Dhawan, S.; Babu, J.; Haridas, V. Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis. Chem. Rev. 2019, 119 (21), 11391–11441, DOI: 10.1021/acs.chemrev.9b00153).

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5th Feb 2020