Tissue engineering research at IIT Delhi

Recent advances of Tissue engineering could develop several tissues in laboratory, but regenerating tissue-to-tissue interface is still a challenging proposition. Intervertebral disc has a gradient of cartilagenous interface which plays important role in biomechanics of Spine. A biomimetic scaffold has been developed by covalent tethering of chondroitin sulphate with Silk fibrous scaffold. Culturing human chondrocytes on such lamellar scaffold could replicate complex tissue interface, as evidenced by staining with Safranin-O dye, showing fibrocartilagenous tissue at outer layers and hyaline cartilage at inner layers of Tissue Engineered construct.